Quinolines and derivatives
Medchemexpress LLC LM11A-31 (dihydrochloride) | 1243259-19-9 | 99.9% | 316.27 | 25 MG
LM11A-31 dihydrochloride is a non-peptide p75NTR (neurotrophin receptor p75) modulator and an orally active, potent proNGF (nerve growth factor) antagonist. It is an amino acid derivative that readily crosses the blood-brain barrier and inhibits p75-mediated cell death. This compound has been shown to reverse cholinergic neurite dystrophy in mouse models of Alzheimer's disease during mid- to late-stage disease progression. It is intended for research use only and is not sold to patients.
- Non-peptide p75NTR modulator
- Orally active and potent proNGF antagonist
- Amino acid derivative with high blood-brain barrier permeability
- Blocks p75-mediated cell death
- Reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models
- Mitigates proNGF accumulation and preserves BRB integrity in animal models
Medchemexpress LLC M-PEG9-amine | 211859-73-3 | 97.0% | 427.53 g/mol | C19H41NO9 | 100 MG
m-PEG9-amine is a methoxy-terminated polyethylene glycol (PEG) linker containing nine ethylene glycol units and a terminal primary amine. It is supplied as a liquid (colorless to light yellow) and is used as a PEG-based linker for proteolysis-targeting chimera (PROTAC) synthesis and as a cleavable linker in antibody-drug conjugate (ADC) development.
- Methoxy-terminated polyethylene glycol (PEG) linker with a terminal primary amine.
- Suitable for use as a PEG-based linker in PROTAC synthesis.
- Functions as a cleavable linker for antibody-drug conjugates (ADCs).
- High purity (97.0%) for research and conjugation workflows.
- Molecular weight about 427.53 g/mol; formula C19H41NO9; CAS 211859-73-3.
- Available in laboratory-scale sizes, including 100 mg, 250 mg, 1 g, and 5 g.
Medchemexpress LLC 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine | 103285-22-9 | MFCD00274123 | 98.0% | 560.59 g/mol | C31H32N2O8 | 10 G
5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine is a DMT-protected 2'-O-methyl uridine nucleoside used as a building block and intermediate for solid-phase oligonucleotide synthesis and for research on modified RNA. It is supplied as a high-purity solid or as a DMSO solution to facilitate incorporation into synthesis workflows.
- DMT-protected 2'-O-methyl uridine suitable for oligonucleotide synthesis.
- High purity (98.03%) for reliable reactions.
- Available as powder and 10 mM solution in DMSO for flexibility.
- Long-term storage stability when kept at recommended temperatures.
- Datasheet, COA, and SDS available to support quality control.
Medchemexpress LLC Amino-PEG7-amine | 332941-25-0 | 99.3% | C16H36N2O7 | 100 MG
Amino-PEG7-amine is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This mechanism allows PROTACs to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. It is intended for research use only.
- Utilized in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Intended for research use only
Medchemexpress LLC Dimidium bromide | 518-67-2 | 98.6% | 100 MG
Dimidium bromide is a biochemical reagent suitable for use as a biological material or organic compound in life science research.
- Biochemical reagent
- Biological material
- Organic compound
- Suitable for life science related research
Medchemexpress LLC DBCO-amine | 1255942-06-3 | 99.1% | 276.34 g·mol-1 | C18H16N2O | 25 MG
DBCO-amine is a dibenzocyclooctyne-containing amine reagent used for strain-promoted alkyne-azide cycloaddition (SPAAC) click chemistry. It is used as a small linker for bioconjugation and the synthesis of antibody-drug conjugates, and is typically handled and stored under anhydrous conditions and in organic solvent solutions for formulation.
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) bioconjugation.
- High purity suitable for synthetic and bioconjugation applications.
- Minimal spacer length reduces steric hindrance in conjugates.
- Compatible with common coupling chemistries for linker installation.
- Soluble in DMSO for straightforward formulation and handling.
Medchemexpress LLC Azido-PEG8-amine | 857891-82-8 | 99.9% | C18H38N4O8 | 50MG
Azido-PEG8-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. This click chemistry reagent contains an Azide group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with Alkyne group molecules. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC Azido-PEG10-amine | 912849-73-1 | 97.0% | C22H46N4O10 | 100 MG
Azido-PEG10-amine is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group. This allows it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups, and also undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Functions as a click chemistry reagent
- Contains an azide group for CuAAc and SPAAC reactions
- Enables reactions with alkyne, DBCO, or BCN groups
- Leverages the ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC mPEG-amine (MW 1000) | 80506-64-5 | 99.2% | (C2H4O)nC3H9NO | 500 MG
mPEG-amine (MW 1000) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. PROTACs are compounds that connect an E3 ubiquitin ligase ligand with a target protein ligand via a linker. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used for the synthesis of PROTACs
- Utilizes ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Benzyl-PEG5-amine | 86770-77-6 | 98.0% | C17H29NO5 | 50 MG
Benzyl-PEG5-amine is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are designed with two distinct ligands connected by a linker; one targets an E3 ubiquitin ligase, and the other targets a specific protein. This mechanism leverages the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- Peg-based protac linker
- Used in the synthesis of protacs
- Utilizes ubiquitin-proteasome system
- Selectively degrades target proteins
Apexbio Technology LLC AMG-900 945595-80-2 200mg
AMG-900 (CAS 945595-80-2) is a small-molecule inhibitor targeting Aurora kinases a group of serine/threonine kinases crucial for mitosis regulation It exhibits potent ATP-competitive inhibitory activity against all three Aurora kinase isoforms resulting in suppression of Aurora-A and Aurora-B autophosphorylation events AMG-900 induces disruption of cellular mitotic processes leading to cell cycle arrest and subsequent apoptotic cell death Preclinically AMG-900 demonstrates activity across multiple tumor cell lines including multidrug-resistant and taxane-resistant variants and inhibits tumor growth in mouse xenograft models suggesting utility for cancer research
Medchemexpress LLC L-azidonorleucine (hydrochloride) | 1454334-76-9 | 98.0% | 200 MG
L-Azidonorleucine hydrochloride is an unnatural amino acid that serves as a methionine surrogate. It is used to label mammalian cell proteins and identify various methionyl-tRNA synthetase (MetRS) mutants. This compound functions as a click chemistry reagent due to its azide group, which enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Unnatural amino acid and methionine surrogate
- Labels mammalian cell proteins
- Identifies methionyl-tRNA synthetase (MetRS) mutants
- Functions as a click chemistry reagent
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC Selenocystamine dih 25g
Selenocystamine dihydrochloride is a selenocysteine derivative that can be used in the synthesis of other active compounds Selenocystamine dihydrochloride can also induce the aggregation of amphiphilic p-sulfonatocalixarene to form supramolecular nanoparticles[1][2][3]
Medchemexpress LLC 2-Octyl-4(1H)-quinolone | 80554-60-5 | >=98.0% | 257.37 | 50 MG
2-Octyl-4(1H)-quinolone is a quinolinone alkaloid that can be isolated from *Ruta graveolens*. It is intended for research use only. It has shown antiproliferative activity against human A2780 cells with an IC50 of 12 μM after 2 days by Alamar blue assay. The compound is a solid, white to off-white in color, with the formula C17H23NO. It is classified under Alkaloids and Other Alkaloids, and its initial source is from the plants Rutaceae, specifically *Ruta graveolens Linn.*.
- Quinolone alkaloid.
- Isolated from *Ruta graveolens*.
- For research use only.
- Exhibits antiproliferative activity against human A2780 cells with an IC50 of 12 μM after 2 days by Alamar blue assay.
- Solid, white to off-white in color.
- Chemical formula C17H23NO.
- Classified under alkaloids.
- Sourced from Rutaceae, *Ruta graveolens Linn.*.
